What Is 2-(Thiophen-2-yl)phenol (CAS 106584-13-8)? Properties, Uses, and Supplier Information

2-(Thiophen-2-yl)phenol, also known as 2-(2-thienyl)phenol, is an aromatic sulfur-containing phenolic compound identified by CAS No. 106584-13-8. Its molecular formula is commonly represented as C₁₀H₈OS, with a calculated molecular weight of approximately 176.23 g/mol. The molecule contains a phenol group and a thiophene ring connected through a carbon–carbon bond, giving it both hydrogen-bonding functionality and heteroaromatic character.

If you are looking for more details, kindly visit our website.

In my experience, buyers usually evaluate this material as a research chemical, synthetic intermediate, or building block rather than as a high-volume commodity. Its final suitability depends on purity, physical form, analytical documentation, packaging, and the intended reaction route. At Maison Chemical, we support qualified inquiries by reviewing the required specification, quantity, documentation, and delivery destination before confirming supply details.

Identity and Core Properties

2-(Thiophen-2-yl)phenol combines two chemically important structural features. The phenolic hydroxyl group can participate in hydrogen bonding and may be further modified through etherification, esterification, or other functional-group transformations. The thiophene ring is an electron-rich five-membered heteroaromatic system that can contribute to the reactivity and electronic properties of downstream molecules.

The compound should be distinguished from positional isomers and related materials such as 3-(thiophen-2-yl)phenol, 2-phenylthiophene, or substituted thiophenols. A correct CAS number, structure confirmation, and analytical comparison are important because small positional changes can affect reaction behavior, chromatographic retention, and final product performance.

The table provides an identity-level starting point, not a substitute for a batch-specific certificate of analysis. Physical properties such as appearance, melting behavior, purity, water content, and residual solvents should be confirmed against the supplier’s current specification. If a buyer needs an exact value for a process or regulatory file, I recommend requesting the relevant analytical documents before purchase.

Potential Functions and Uses

Synthetic building block

The most practical role of 2-(thiophen-2-yl)phenol is as an intermediate for laboratory and process chemistry. The phenolic hydroxyl group offers a site for selective derivatization, while the thiophene ring can remain as part of the target molecular framework. This combination may be useful when a project requires an aromatic scaffold containing both oxygen and sulfur heteroatoms.

Potential transformations can include protection of the phenol, preparation of aryl ethers, coupling-related routes, and incorporation into more complex medicinal or materials-oriented structures. These are application possibilities rather than universal performance claims, because the appropriate chemistry depends on catalysts, solvents, reaction temperature, stoichiometry, and substrate compatibility.

Pharmaceutical and fine-chemical research

In pharmaceutical intermediate research, this compound may be investigated as a starting material for the synthesis of structurally diverse molecules. The presence of a phenolic group allows chemists to introduce linkers or modify polarity, while the thiophene ring can be retained as a heteroaromatic fragment. It should not, however, be described as an active pharmaceutical ingredient or as an approved pharmaceutical substance without project-specific regulatory evidence.

Materials and functional molecule research

Thiophene-containing aromatic compounds are also studied in the development of functional organic molecules, sensors, and electronic or photochemical research systems. For 2-(thiophen-2-yl)phenol, the relevance of these applications must be established experimentally because performance depends on the complete molecular design, not on this intermediate alone. Buyers should therefore evaluate it according to the intended synthesis and downstream product requirements.

Material Options and Key Specifications

For procurement, I generally separate the material into three specification levels: identity confirmation, routine research grade, and project-specific process grade. Identity confirmation normally focuses on CAS alignment, molecular structure, and an analytical profile. A project-specific grade may add tighter limits for purity, water, residual solvents, metals, or particular impurities.

For more information, please visit Maison Chemical.

• Identity: CAS number, molecular formula, molecular weight, and structural confirmation.
• Purity: A defined analytical method and acceptance limit, usually supported by chromatographic data.
• Appearance: The agreed description of the supplied solid or other physical form.
• Impurity profile: Relevant starting materials, regioisomers, reaction by-products, and degradation products.
• Packaging: Container type, net weight, labeling, and protection from unsuitable storage conditions.
• Documentation: Certificate of analysis, safety data sheet, technical data, and shipping information where applicable.

I avoid presenting an unverified melting point, color, assay, or storage life as a guaranteed value. Such parameters can vary with manufacturing route, purification, residual solvent, and analytical method. The most reliable procurement practice is to request a current batch specification and representative documentation for the exact material being offered.

Handling and Storage Considerations

Because this compound contains a phenolic group and a sulfur-containing heteroaromatic ring, it should be handled as a research or industrial chemical in accordance with the applicable safety data sheet. Personnel should use suitable laboratory controls, protective equipment, and ventilation based on the quantity and operation. I recommend avoiding direct contact, unnecessary dust generation, and uncontrolled exposure during weighing or transfer.

Storage should follow the supplier’s SDS and the buyer’s chemical-management procedures. The container should remain properly closed, clearly labeled, and protected from conditions that could cause contamination or degradation. Compatibility with the packaging material, temperature limits, and any light or moisture precautions should be verified before long-term storage.

How Buyers Should Select a Supplier

Confirm the exact chemical identity

The first step is to provide the CAS number, preferred name, molecular structure, required purity, and intended use. This reduces the risk of receiving a positional isomer or a similarly named thiophene derivative. If the material will enter a regulated development program, the buyer should also define the documentation format and traceability expectations at the beginning.

Match quality to the application

A small-scale discovery project may require a reliable research-grade material with a clear analytical profile. A process-development project may require more detailed impurity control, repeatability between batches, and a defined packaging configuration. I recommend avoiding the assumption that the highest nominal purity is automatically the best choice; the useful specification is the one that controls impurities relevant to the buyer’s reaction and downstream process.

Review supply and logistics

Before placing an order, buyers should confirm available quantity, production or preparation lead time, packaging size, export requirements, and shipping restrictions. They should also ask whether a sample, pre-shipment documentation, or analytical review is available. Lead time and minimum order quantity can vary by stock status, batch availability, and whether custom preparation is required, so these details should be quoted rather than assumed.

Supplier Support from Maison Chemical

At Maison Chemical, I approach 2-(thiophen-2-yl)phenol inquiries by first clarifying the customer’s technical and commercial requirements. We can review the requested CAS number, target quantity, purity expectation, packaging, destination, and required documents before discussing a supply arrangement. This approach helps distinguish a one-time research purchase from a repeat or process-development requirement.

For qualified B2B buyers, the inquiry can include the intended application, preferred analytical method, required delivery date, and any restrictions on solvents or impurities. We can then determine which information can be confirmed for the available material and identify whether additional technical review is needed. Any specification, lead time, or commercial term should be confirmed in writing for the specific order.

Key Takeaways for Buyers

• 2-(Thiophen-2-yl)phenol is a phenolic, thiophene-containing aromatic compound with CAS No. 106584-13-8.
• Its commonly represented formula is C₁₀H₈OS, and its approximate molecular weight is 176.23 g/mol.
• Its main value is as a potential synthetic intermediate for pharmaceutical, fine-chemical, and functional-molecule research.
• Application suitability depends on the complete synthesis, not only on the name or nominal purity of the starting material.
• Buyers should verify batch-specific purity, impurity profile, physical form, SDS, CoA, packaging, MOQ, and lead time.

Conclusion and Next Steps

2-(Thiophen-2-yl)phenol, CAS 106584-13-8, is a sulfur-containing phenolic building block that may support the synthesis of pharmaceutical intermediates, fine chemicals, and research molecules. Its phenol and thiophene functionalities provide useful opportunities for molecular modification, but the correct evaluation must be based on the buyer’s reaction route and downstream specification. The most dependable purchasing decision combines confirmed identity, suitable analytical quality, safe handling information, and realistic supply terms.

To begin a B2B inquiry with Maison Chemical, send the required quantity, target purity, application or synthesis stage, packaging preference, destination, and documentation requirements. I can then help organize the technical questions needed for a product and supply review. This information provides a practical basis for confirming whether the available material fits your research, development, or manufacturing project.

If you want to learn more, please visit our website 2-(thiophen-2-yl)phenol CAS 106584-13-8.