4-(Hydroxymethyl)phenylboronic Acid CAS 59016-93-2: A Buyer’s Guide to Specifications, Applications, and Sourcing

4-(Hydroxymethyl)phenylboronic acid, CAS 59016-93-2, is an aromatic boronic acid used primarily as a functional intermediate in organic synthesis, especially in palladium-catalyzed Suzuki–Miyaura coupling. Its molecular formula is C₇H₉BO₃, and its molecular weight is approximately 151.96 g/mol. The molecule combines a boronic acid group with a hydroxymethyl substituent, giving buyers two useful functional handles for designing substituted biaryl compounds and further derivatization.

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For procurement, I recommend evaluating more than the CAS number alone. Buyers should confirm identity, assay, water content, residual solvents, physical form, packaging, documentation, and supply continuity against the intended reaction and project scale. Maison Chemical can support quotation and technical discussions for 4-(Hydroxymethyl)phenylboronic acid based on required grade, quantity, documentation, and delivery destination.

Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical development teams, fine chemical manufacturers, contract research organizations, process chemists, and purchasing departments sourcing organic boronic acids. It is also useful for laboratories comparing building blocks for medicinal chemistry or route development. The recommendations apply to both early-stage screening and larger commercial sourcing, although the required quality documentation may differ by application.

Buyers should use this material when they need an aryl boronic acid containing an additional hydroxymethyl group. The hydroxymethyl functionality may be retained for later conversion, protection, or conjugation, while the boronic acid can participate in carbon–carbon bond-forming chemistry. Actual suitability depends on the reaction conditions, substrate combination, purification method, and downstream quality requirements.

Basic Chemical Context and Core Functions

4-(Hydroxymethyl)phenylboronic acid belongs to the class of aryl boronic acids. In a typical Suzuki–Miyaura coupling, the boronic acid group reacts with an aryl or vinyl halide in the presence of a suitable catalyst and base to form a new carbon–carbon bond. The hydroxymethyl group remains available as a separate functional site, although its stability and compatibility must be assessed under the selected reaction conditions.

The compound is generally purchased as a research or manufacturing intermediate rather than as a finished active ingredient. Its value comes from its ability to introduce a substituted phenyl group while preserving a primary alcohol for subsequent chemistry. Because boronic acids can be sensitive to moisture, heat, storage conditions, and prolonged exposure to certain media, buyers should review the supplier’s recommended handling information before placing a large order.

Specification Overview: What Buyers Should Confirm

A reliable specification should identify the material unambiguously and define the quality attributes that matter for the intended use. The CAS number and molecular formula provide a starting point, but they do not by themselves prove batch quality. I recommend requesting a current specification sheet and a batch-specific certificate of analysis before approval.

For route development, a buyer may accept a practical research-grade specification if the material performs consistently in screening. For process development or regulated manufacturing, the purchasing specification may need tighter controls, defined analytical methods, change notification expectations, and documented traceability. I advise buyers to establish these requirements before comparing quotations because a lower unit price may not represent a lower total procurement cost.

Application Matching

Suzuki–Miyaura Coupling

The most direct application is use as an aryl boronic acid coupling partner. It can be considered when a synthesis requires a phenyl fragment bearing a hydroxymethyl substituent at the para position. The reaction outcome depends on the halide or pseudohalide partner, catalyst system, base, solvent, temperature, concentration, and work-up procedure, so the compound should be evaluated in the complete reaction context rather than in isolation.

Further Functionalization of the Hydroxymethyl Group

The hydroxymethyl group may provide a route to additional derivatives, such as protected alcohols, ethers, esters, or other functionalized intermediates. Whether a transformation is appropriate depends on chemoselectivity and the order in which the boronic acid and alcohol are used. Buyers should discuss planned downstream chemistry with their technical team before selecting between the free boronic acid and a protected or esterified alternative.

Medicinal Chemistry and Fine Chemical Research

In discovery research, this building block can help chemists explore structure–activity relationships involving substituted biaryl or polyfunctional aromatic compounds. Its relatively compact structure may be useful when a project needs both an aromatic coupling site and a handle for later molecular diversification. Research teams should still confirm purity, identity, and reaction performance in their own systems because a catalog specification does not replace project-specific verification.

Types and Material Options to Compare

The most important comparison is often between the free boronic acid and a protected boronate ester, such as a pinacol ester. The free acid may be preferred when the reaction procedure is already developed for that form, while an ester may offer different handling or storage behavior in some synthetic workflows. These forms are not automatically interchangeable on a one-to-one basis, so the buyer should check stoichiometry, assay calculation, molecular weight, and reaction equivalence.

Buyers may also compare research-grade, development-grade, and production-oriented supply. These labels can mean different things between suppliers, so I recommend focusing on measurable specifications and documentation rather than grade names alone. If the material will enter a validated process, ask for a formal quality discussion covering analytical methods, batch consistency, packaging, and change-control communication.

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Buyer Selection Framework

1. Define the Intended Use

Start by documenting whether the material is for reaction screening, route development, pilot production, or routine manufacturing. Record the expected annual volume, batch size, delivery schedule, and whether the compound will be used in a regulated environment. This information helps the supplier recommend an appropriate package size and documentation level.

2. Set the Critical Quality Attributes

Identify the attributes that can affect your chemistry, including assay, water, residual solvents, impurity profile, appearance, and particle or powder handling characteristics where relevant. Do not request unnecessarily restrictive limits without a technical reason, because excessive specifications can increase cost and limit supply options. At the same time, avoid accepting a specification that does not control impurities known to interfere with your reaction or purification.

3. Review Analytical Evidence

Request a batch-specific COA and confirm that the reported methods are suitable for the material. Depending on the project, useful evidence may include chromatographic purity, NMR identity confirmation, water testing, and residual solvent information. The exact analytical package should match your internal quality system and the risk level of the application.

4. Evaluate Commercial Terms

Compare price by usable quantity and quality level rather than by headline price alone. Confirm the minimum order quantity, available pack sizes, lead time, shipping conditions, payment terms, and whether samples can be supplied for qualification. For planning purposes, buyers should request a quotation with a stated validity period because availability and logistics can change.

5. Check Storage and Packaging

Ask how the material is packed, labeled, sealed, and protected during transportation. The supplier should provide handling and storage recommendations through the SDS or technical documentation. Before purchasing a large quantity, verify that the receiving site can sample and store the product under the recommended conditions.

Pricing, MOQ, and Lead-Time Considerations

Pricing for this type of specialty intermediate can vary with purity requirements, batch size, packaging, analytical testing, and production status. A laboratory order may have a higher unit cost than a development or production quantity because smaller packs require more handling per kilogram. Buyers should request tiered pricing at quantities such as 100 g, 1 kg, and larger project volumes when those quantities reflect actual demand.

Minimum order quantity and lead time should be confirmed in writing for the required grade. A supplier may have material available from stock, while another may need production scheduling or additional testing. If your project has a fixed manufacturing date, I recommend qualifying an initial sample early and requesting a delivery plan that separates sample approval from routine supply.

Common Sourcing Mistakes

One common mistake is ordering solely by CAS number without confirming the requested form, purity basis, and packaging. Another is comparing a free boronic acid with a boronate ester without recalculating molecular equivalents. Buyers also sometimes overlook water and residual solvent information until a reaction shows inconsistent conversion or purification performance.

A further risk is treating a single successful laboratory experiment as proof of long-term supply suitability. For recurring demand, ask about lot traceability, batch-to-batch documentation, forecast requirements, and communication procedures for specification or manufacturing changes. These steps can reduce avoidable interruptions without requiring unsupported assumptions about future performance.

Maison Chemical Supplier Support

At Maison Chemical, I approach sourcing discussions by first clarifying the customer’s application, target quantity, quality requirements, and delivery destination. We can discuss 4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 in relation to identity documentation, specification review, packaging, quotation structure, and project timing. Where a buyer has a defined internal standard, we can use that information as the basis for a more relevant supply assessment.

For an efficient inquiry, please include the requested quantity, preferred grade or assay requirement, intended use, documentation needs, target delivery date, and destination country. If you are still developing the process, explain whether you need a small evaluation sample or a scalable supply option. This allows us to respond with a quotation and supply discussion aligned with your actual procurement stage.

Key Takeaways

• 4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 is an aromatic boronic acid intermediate with a para-hydroxymethyl substituent.
• Its molecular formula is C₇H₉BO₃, with an approximate molecular weight of 151.96 g/mol.
• The main application focus is carbon–carbon bond formation, particularly Suzuki–Miyaura coupling, followed by further functionalization where appropriate.
• Buyers should confirm assay, identity, water, residual solvents, physical form, COA, SDS, packaging, MOQ, and lead time.
• The free boronic acid and protected boronate esters should be compared according to reaction design, handling requirements, and equivalent calculation.

Conclusion: How to Make the Right Purchase Decision

The right way to source 4-(Hydroxymethyl)phenylboronic acid is to match the material specification and supplier support to the intended chemistry and project stage. For early research, identity and practical reaction performance may be the main priorities; for process or routine manufacturing, documented quality, traceability, consistency, and supply planning become increasingly important. A structured comparison helps prevent low-price decisions that create higher downstream costs.

As your next step, prepare a short inquiry containing the CAS number, required quantity, target specification, documentation list, packaging preference, and delivery schedule. Send these details to Maison Chemical so we can review the requirement and discuss a suitable supply route for your organic boronic acid program.

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