Guide to 4-Propylphenylboronic Acid CAS 134150-01-9: Properties, Uses, and Supplier Selection

4-Propylphenylboronic acid, also known as 4-propylbenzeneboronic acid, is an aryl boronic acid used primarily as a coupling partner in synthetic organic chemistry. Its CAS number is 134150-01-9, and its molecular formula is generally represented as C₉H₁₃BO₂, with a calculated molecular weight of approximately 164.01 g/mol. At Maison Chemical, we position this material for research, process development, and pharmaceutical or agrochemical intermediate synthesis where a para-propyl-substituted aryl building block is required.

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The most important value of this compound is its boronic acid functional group, which can participate in palladium-catalyzed Suzuki–Miyaura coupling reactions with suitable aryl or vinyl halides. The propyl substituent changes the electronic and steric character of the aromatic ring and can help introduce a hydrophobic alkyl group into a target molecule. Final suitability depends on the reaction system, substrate combination, purity requirement, packaging, and analytical documentation requested by the buyer.

Who This Guide Is For

This guide is intended for procurement managers, process chemists, medicinal chemistry teams, custom synthesis companies, and distributors evaluating 4-propylphenylboronic acid as a specialty organic intermediate. It is also useful for buyers comparing suppliers before requesting a quotation or technical package. I focus here on practical selection criteria rather than presenting unverified performance claims or assuming that one specification fits every project.

What Is 4-Propylphenylboronic Acid?

4-Propylphenylboronic acid contains an aromatic ring bearing two key substituents: a boronic acid group and a propyl group positioned para to it. The boronic acid group is the reactive site commonly used for carbon–carbon bond formation, while the propyl group remains part of the final molecular structure after successful coupling. This combination makes the compound relevant when a synthesis requires both an aryl coupling handle and a defined hydrophobic substituent.

In a typical Suzuki–Miyaura reaction, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide in the presence of a suitable palladium catalyst, base, solvent, and reaction atmosphere. Reaction conditions must be developed for the specific substrate pair because catalyst loading, base selection, water content, temperature, and purification behavior can influence conversion. A boronic acid should therefore be evaluated as part of the complete reaction route, not as an isolated guarantee of yield.

Core Properties and Specification Considerations

The identifiers and calculated properties below provide a starting point for purchasing and laboratory documentation. Buyers should confirm the supplier’s current certificate of analysis because appearance, assay, impurity profile, water content, and residual solvent limits can vary by production route and requested grade.

For technical purchasing, I recommend requesting at least an assay specification, identity data, water content where relevant, and a description of known or controlled impurities. If the material will enter a regulated development program, the buyer may also need residual solvent information, elemental impurity considerations, batch traceability, and a change-notification policy. These requirements should be agreed before production rather than added after shipment.

Application Matching: Where It May Fit

Pharmaceutical and Medicinal Chemistry

Medicinal chemistry teams may use 4-propylphenylboronic acid to prepare biaryl, aryl-heteroaryl, or related substituted structures during discovery and route exploration. Its value is greatest when the target molecule specifically benefits from a para-propyl-substituted aromatic fragment. The compound can support parallel synthesis, provided the project team has confirmed compatibility with its chosen coupling partner and catalyst system.

Agrochemical and Fine Chemical Synthesis

Specialty chemical developers may consider this building block during the preparation of candidate intermediates containing hydrophobic aromatic regions. The boronic acid functionality can offer a practical disconnection for assembling carbon–carbon bonds in multi-step synthesis. However, commercial process suitability must be verified through scale-relevant experiments, impurity tracking, and isolation studies.

Research and Custom Synthesis

Universities, contract research organizations, and custom synthesis laboratories may purchase this material in smaller quantities for method development or reference work. In these cases, packaging flexibility, rapid documentation, and reliable identity confirmation can be as important as the nominal assay. I recommend matching the pack size to the expected screening volume while allowing enough material for repeat experiments and analytical investigation.

How to Select the Right Material and Supplier

Step 1: Define the Intended Use

Begin by identifying whether the product is needed for exploratory research, process development, commercial intermediate manufacture, or distribution. The intended use determines the acceptable assay range, documentation depth, packaging format, and supply continuity expectations. A research project may prioritize small-pack availability, while a process program may require lot consistency and a defined impurity-control strategy.

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Step 2: Confirm Identity and Analytical Requirements

Ask the supplier to confirm the chemical name, CAS number, molecular formula, molecular weight, and available analytical methods. Depending on the project, the technical package may include chromatographic purity, water measurement, NMR data, mass spectrometry data, or other identity evidence. I advise buyers to compare the actual certificate format and test methods rather than relying only on a product name listed in a catalogue.

Step 3: Review Supply, Packaging, and Logistics

Confirm the available quantity, packaging material, storage recommendation, shipment conditions, and estimated lead time before issuing a purchase order. There is no universal MOQ or lead time for this specialty chemical because these factors depend on stock status, batch size, production planning, and destination. For an initial inquiry, providing the required quantity, target delivery region, intended grade, and documentation needs allows the supplier to give a more realistic quotation.

Step 4: Evaluate Scale-Up Risk

If the compound will move from milligram research to gram or kilogram production, ask whether the same manufacturing route and release criteria can be maintained across batches. Buyers should also discuss whether the supplier can support a retained sample, batch traceability, and investigation of out-of-specification results. These controls help reduce the risk of discovering avoidable material differences after process development has already advanced.

Common Buyer Mistakes

One frequent mistake is selecting a boronic acid solely by CAS number without reviewing the assay basis or impurity profile. Another is assuming that a material suitable for a small-scale reaction will automatically perform identically at larger scale. Buyers may also overlook packaging compatibility, moisture exposure, import documentation, or the need for a formal change-notification arrangement.

A second issue is requesting a quotation without explaining the project stage. A supplier cannot accurately assess technical support, stock availability, or documentation requirements when the inquiry contains only a product name and quantity. I recommend sending a concise purchasing brief that includes the CAS number, target amount, delivery location, preferred pack size, required analytical documents, and expected repeat demand.

Pricing, MOQ, and Lead-Time Guidance

Pricing for 4-propylphenylboronic acid is influenced by quantity, purity target, packaging, production route, and whether the material is available from existing stock. Smaller research packs generally carry a different unit economics profile from bulk or scheduled production quantities. Because market conditions and inventory change, I recommend treating any quote as project-specific rather than assuming a fixed public price.

For planning, buyers should request both an immediate-stock option and a production option when available. This comparison can clarify the trade-off between faster delivery and lower unit cost, while also showing whether a larger order requires a manufacturing slot. Maison Chemical can review quantity tiers, documentation requirements, and repeat-order expectations so that the supply proposal is aligned with the actual procurement plan.

Maison Chemical Supplier Support

At Maison Chemical, I approach 4-propylphenylboronic acid inquiries by first confirming the product identity and intended application. We can discuss suitable quantity levels, available specifications, packaging expectations, and the analytical documents required for internal approval. Where a standard specification does not match the project, we can evaluate the request before confirming whether a customized supply plan is practical.

Our role is not limited to quoting a chemical name. We aim to help buyers compare technical requirements with supply conditions, identify missing information early, and establish a clear basis for repeat purchasing. Final availability, lead time, and documentation should always be confirmed in the quotation and commercial order documents.

Key Takeaways

• 4-Propylphenylboronic acid, CAS 134150-01-9, is an aryl boronic acid used mainly as a synthetic coupling building block.
• Its calculated molecular weight is approximately 164.01 g/mol, and its commonly represented formula is C₉H₁₃BO₂.
• Its suitability depends on the target reaction, coupling partner, purity requirement, and process scale.
• Before ordering, confirm assay, identity data, impurity controls, packaging, MOQ, lead time, and documentation.
• A clear technical purchasing brief helps Maison Chemical provide a more accurate and useful supply proposal.

Conclusion and Next Steps

4-Propylphenylboronic acid CAS 134150-01-9 is best understood as a specialized aryl building block for carbon–carbon bond formation, particularly in Suzuki–Miyaura coupling development. It may fit pharmaceutical, agrochemical, fine chemical, and research applications when the target structure requires a para-propyl-substituted aromatic fragment. The correct purchase decision should be based on verified identity, project-specific analytical requirements, scale, and supply reliability.

To begin, send Maison Chemical your required quantity, application stage, target specification, destination, preferred packaging, and documentation list. We can then assess available supply options, clarify MOQ and lead-time expectations, and prepare a quotation for your review. This process gives your team a practical basis for approving and sourcing 4-propylphenylboronic acid with fewer avoidable procurement risks.

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