What Is Pyridine-3-boronic Acid CAS 1692-25-7? Properties, Uses, and Specifications

Pyridine-3-boronic acid, also called 3-pyridylboronic acid, is an organoboron intermediate used mainly to introduce a pyridin-3-yl group into more complex molecules. Its CAS Registry Number is 1692-25-7, and its molecular formula is commonly represented as C₅H₆BNO₂, with a calculated molecular weight of approximately 122.92 g/mol. In practical synthesis, its most important function is participation in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions with suitable aryl or heteroaryl halides.

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At Maison Chemical, we view this material as a functional building block rather than a simple commodity chemical. Buyers should evaluate not only identity and assay, but also water content, impurity profile, packaging, stability, documentation, and suitability for the intended reaction route. The exact commercial specification should always be confirmed against the current product specification sheet and safety data sheet.

Identity and Core Chemical Function

What the molecule contains

Pyridine-3-boronic acid combines a pyridine ring with a boronic acid group positioned at the 3-position. The pyridine nitrogen contributes heteroaromatic character and can influence solubility, coordination behavior, and reaction performance. The boronic acid group provides a useful carbon–boron bond that can be transformed into a new carbon–carbon bond under appropriate coupling conditions.

The material is generally handled as a solid intermediate. Although the formula and molecular weight are useful for identification and calculation, they do not by themselves define the quality of a commercial batch. Buyers should use the supplier’s certificate of analysis, analytical data, and lot-specific documentation to confirm the material received.

Why the boronic acid group matters

In Suzuki–Miyaura coupling, the boronic acid functionality can react with an aryl, heteroaryl, or vinyl halide in the presence of a suitable palladium catalyst and base. This enables the preparation of biaryl and heteroaryl products under conditions selected for the substrate and process. The pyridine ring remains part of the coupled product, making the intermediate valuable for medicinal chemistry and other discovery applications.

Reaction behavior depends on more than the name of the starting material. Catalyst selection, base, solvent, temperature, substrate electronics, water content, and reaction time can all influence conversion and impurity formation. For this reason, we recommend treating Pyridine-3-boronic Acid CAS 1692-25-7 as a route-specific raw material that should be evaluated in the customer’s actual process.

Common Uses and Application Scenarios

Pharmaceutical and medicinal chemistry

The principal use of this compound is as a building block for synthesizing pyridyl-substituted molecules. Medicinal chemistry teams may use it to prepare analogues during structure–activity relationship studies, where rapid variation of aromatic substituents is important. It can also support the preparation of advanced intermediates for later functionalization.

Its value comes from combining a reactive boronic acid handle with a nitrogen-containing aromatic ring. This combination can help chemists introduce polarity, coordination sites, or a heteroaryl motif into a target structure. Actual suitability depends on the target molecule, reaction sequence, and downstream purification requirements.

Agrochemical and specialty synthesis

Pyridyl fragments are present in some specialty chemical research programs, including the development of crop-protection intermediates and performance chemicals. Pyridine-3-boronic acid may be considered when a synthetic route requires controlled installation of a 3-pyridyl group. Use in these sectors should be assessed against the customer’s regulatory, analytical, and process-development requirements.

Research and scale-up chemistry

Academic, contract research, and process-development laboratories may purchase this material in small quantities for route screening, optimization, or intermediate preparation. A material that performs adequately at milligram scale may still require additional assessment before kilogram-scale use. Batch consistency, filtration behavior, packaging, and supply continuity become increasingly important as the project advances.

Types and Material Options Buyers May Consider

Commercial purchasing decisions are often based on more than one grade or pack size. A buyer may need a research quantity for initial screening, a larger package for process development, or a planned supply arrangement for repeated production campaigns. The required purity level should be linked to the reaction and purification strategy rather than selected solely by a generic label such as “high purity.”

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Maison Chemical can discuss the appropriate material format according to the buyer’s application, order quantity, and documentation needs. We do not recommend assuming that one specification is suitable for every synthesis. A technical review before ordering can help identify whether additional testing or a custom quality discussion is necessary.

Key Specifications for Pyridine-3-boronic Acid CAS 1692-25-7

The basic identity data commonly used for procurement are shown below. Molecular weight is approximately 122.92 g/mol, and the molecular formula is C₅H₆BNO₂. The CAS number, 1692-25-7, should appear consistently across the quotation, product specification, certificate of analysis, and shipping paperwork.

Buyers should avoid treating an advertised purity value as a complete quality assessment. The analytical method, sample basis, test date, and acceptance limits should be reviewed, especially when the compound will be used in a regulated or scale-sensitive project. If a melting range, water limit, or storage condition is important to the process, it should be confirmed in writing rather than inferred from a general catalog description.

Handling, Storage, and Safety Considerations

Pyridine-3-boronic acid should be handled according to its current safety data sheet and the customer’s laboratory or plant procedures. Personnel should use appropriate protective equipment, avoid generating dust, and work with suitable ventilation and containment. The material should not be treated as harmless simply because it is a research intermediate.

Storage conditions should be selected using the supplier’s documented recommendations, packaging design, and local environmental conditions. Buyers may request guidance on temperature, moisture protection, container closure, shelf life, and retest policy before placing an order. A commonly discussed temperature range for some chemical storage programs is 2–8 °C, but this value should not be assumed for every batch or package unless it is stated in the applicable product documentation.

Before production use, customers should confirm compatibility with their weighing, charging, and waste-handling procedures. If the compound is used in a coupling reaction, the complete reaction mixture also requires separate hazard assessment because catalysts, bases, solvents, and halide substrates may introduce additional risks. Proper process safety review remains the responsibility of the end user.

How Buyers Should Select a Supplier

Review technical evidence

Start by requesting the current specification sheet, safety data sheet, and representative or lot-specific certificate of analysis. Confirm the analytical methods used for assay and related substances, and ask whether water, residual solvents, and elemental impurities can be reported when relevant. Evidence should be matched to the intended use instead of relying only on a product title or a single purity number.

Assess supply and service capability

For ongoing projects, discuss package sizes, minimum order quantity, production or replenishment lead time, export documentation, and shipping conditions. A supplier should be able to explain which information is standard and which items require project-specific confirmation. It is also useful to establish how nonconformity, retesting, packaging damage, and technical questions will be handled.

At Maison Chemical, we support buyers by clarifying product identity, specification requirements, packaging expectations, and application context before quotation. Depending on the project, we can discuss sample evaluation, batch documentation, repeat-order planning, and communication between technical and purchasing teams. Final availability, lead time, and commercial terms are confirmed case by case.

Key Takeaways

• Pyridine-3-boronic acid is a heteroaryl boronic acid intermediate identified by CAS 1692-25-7.
• Its formula is commonly listed as C₅H₆BNO₂, with an approximate molecular weight of 122.92 g/mol.
• Its main synthetic role is introducing a pyridin-3-yl group through suitable cross-coupling chemistry.
• Assay, water content, related substances, residual solvents, packaging, and documentation should be reviewed before purchase.
• Storage and handling requirements must follow current supplier documentation and the user’s safety procedures.

Conclusion and Next Steps

Pyridine-3-boronic acid CAS 1692-25-7 is a useful building block for preparing pyridyl-containing pharmaceutical, agrochemical, and specialty chemical intermediates. Its practical value depends on verified identity, suitable purity, controlled impurities, appropriate handling, and reliable supply rather than on the chemical name alone. The correct buying decision therefore starts with the intended reaction and ends with a documented, lot-specific specification review.

If you are evaluating this material, prepare the target quantity, required purity, application, packaging preference, destination, and documentation requirements before requesting a quotation. Contact Maison Chemical with these details so we can review the appropriate supply option, clarify technical documents, and discuss a practical procurement plan for your project.

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