4-(Hydroxymethyl)phenylboronic Acid CAS 59016-93-2: A Buyer’s Guide to Specifications, Applications, and Supplier Selection

I use this guide to help B2B buyers evaluate 4-(Hydroxymethyl)phenylboronic acid, CAS 59016-93-2, before requesting a quotation or approving a supplier. This compound is an aromatic boronic acid with a para-hydroxymethyl substituent, making it useful as a building block for Suzuki–Miyaura coupling and for further functionalization through its alcohol group. Its commonly assigned molecular formula is C₇H₉BO₃, with a molecular weight of approximately 151.96 g/mol. For purchasing, I recommend confirming identity, assay, appearance, water content, residual solvents, packaging, and batch-specific documentation rather than relying on a name alone.

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Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical researchers, medicinal chemistry teams, specialty chemical distributors, procurement departments, and manufacturers sourcing organic boronic acids. It is also relevant to laboratories that need a multifunctional intermediate for route development or scale-up. I focus on practical buying decisions: what the material is, where it may fit, which specifications matter, and how to compare suppliers responsibly.

The compound may be ordered for research quantities, process-development campaigns, or larger manufacturing programs. The appropriate grade and packaging depend on the intended reaction, analytical controls, regulatory requirements, and expected consumption. A small discovery project may prioritize rapid sample availability, while a production buyer may place greater emphasis on batch consistency, change control, and supply continuity.

Basic Chemical Context

4-(Hydroxymethyl)phenylboronic acid contains two chemically useful functional groups on the same benzene ring: a boronic acid group and a primary hydroxymethyl group. The boronic acid can participate in palladium-catalyzed carbon–carbon coupling with suitable electrophilic partners, especially aryl or heteroaryl halides under an appropriate reaction system. The hydroxymethyl group can also support later conversion to ethers, esters, halides, or other derivatives, depending on the synthetic route.

The para arrangement can be valuable when a project requires a relatively defined spatial relationship between the coupling site and the alcohol-containing substituent. However, the actual performance depends on reaction conditions, substrate structure, catalyst, base, solvent, water content, temperature, and work-up. I therefore treat the compound as a versatile intermediate, not as a guarantee of yield or process suitability in every synthesis.

Specifications Buyers Should Review

Identity and Composition

At a minimum, I recommend requesting the product name, CAS number, molecular formula, molecular weight, structural representation, and a batch or lot number. CAS 59016-93-2 should be checked against the supplier’s certificate of analysis and analytical data. For identity confirmation, buyers commonly request techniques such as proton NMR, carbon NMR, infrared spectroscopy, mass spectrometry, or chromatographic data, subject to the supplier’s documentation package.

Purity should always be interpreted together with the analytical method. A stated purity of 98% or 99% is not fully meaningful unless the buyer understands whether it refers to area percent, assay by an absolute method, or another calculation. I also recommend asking whether the result is representative of the quoted batch and whether the supplier can provide a lot-specific certificate rather than a generic specification sheet.

Handling and Stability Information

Boronic acids can be sensitive to storage, moisture, heat, and prolonged exposure to unsuitable conditions, although the practical stability profile must be established for the specific material and package. I ask suppliers to state recommended storage conditions, retest or shelf-life policy, container type, and transport precautions. If the material is intended for a moisture-sensitive route, water content and packaging integrity may deserve the same attention as nominal assay.

For routine laboratory work, buyers should use clean, dry tools and minimize unnecessary exposure of the container to ambient humidity. For scale-up, I recommend confirming whether the supplier has stability data from retained samples or a documented retest program. These checks do not replace a buyer’s own compatibility and stability assessment, but they provide a more reliable basis for procurement.

Application Matching

Suzuki–Miyaura Coupling

The primary application opportunity is use as an aryl boronic acid coupling partner. It may be evaluated with aryl halides, heteroaryl halides, or related electrophiles to construct biaryl or heteroaryl–aryl frameworks. The hydroxymethyl substituent remains available for subsequent transformation, which can help shorten a multi-step synthesis when the target requires both a biaryl connection and an alcohol-derived group.

Reaction development should consider the base and solvent system, catalyst loading, ligand selection, temperature, substrate electronics, and the possibility of boronic acid degradation or side reactions. I recommend screening on a small scale before committing to a large purchase. Buyers should also check whether the supplier can provide a consistent impurity profile across batches, because trace contaminants may affect catalyst-sensitive reactions.

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Medicinal Chemistry and Advanced Intermediates

In medicinal chemistry, this compound can serve as a modular aromatic building block for analog generation. The boronic acid enables diversification at one position, while the hydroxymethyl group offers a second handle for polarity adjustment, linker installation, or conversion into another functional group. The best value is usually achieved when the project’s target series specifically benefits from this two-handle structure.

For pharmaceutical process development, I would evaluate more than reaction performance. Important questions include whether impurities are readily removed, whether the material has a reproducible particle or physical profile, and whether the supplier can support documentation at the required level. The compound should not be described as an active pharmaceutical ingredient unless it is part of a separately defined and qualified product pathway.

Buyer Selection Framework

Step 1: Define the Intended Use

First, I clarify whether the requirement is for discovery screening, route scouting, kilo-scale process development, or commercial manufacturing. I then define the expected quantity, target purity, delivery region, packaging preference, and documentation requirements. This prevents buyers from overpaying for specifications they do not need or, conversely, selecting a low-documentation grade for a regulated program.

Step 2: Compare Technical Offers

I compare the same technical fields across suppliers: assay, analytical method, appearance, water, residual solvents, metals if relevant, packaging, storage guidance, and certificate availability. A useful request should ask for a current specification sheet and a representative or batch-specific COA. If the supplier offers custom packaging or special analytical testing, I ask whether those services affect minimum order quantity or lead time.

Step 3: Evaluate Commercial Risk

Price is only one part of the sourcing decision. I also review MOQ, sample policy, production versus stock status, estimated lead time, export documentation, dangerous-goods classification where applicable, and the supplier’s ability to maintain the same specification over repeat orders. Pricing and lead time can change with quantity, purity, packaging, destination, and production scheduling, so I request a written quotation based on the actual delivery requirement.

Common Purchasing Mistakes

One common mistake is treating a catalog listing as a complete technical qualification. A product page may identify the compound, but it may not reveal batch-specific impurity data, water content, or the exact analytical basis of the purity claim. I also advise buyers not to assume that two suppliers using the same CAS number will provide identical physical behavior or documentation.

A second mistake is ordering a large quantity before testing the material in the buyer’s own reaction system. Boronic acid coupling performance can vary with substrate and conditions, so a representative sample and a defined acceptance plan are prudent. Finally, buyers should avoid specifying an unrealistically narrow requirement without confirming that the method is commercially measurable and relevant to the intended use.

How Maison Chemical Can Support Your Evaluation

At Maison Chemical, I position 4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 as a specialty organic boronic acid for customers who need clear technical communication and practical sourcing support. We can discuss the required quantity, target specification, packaging, destination, and documentation before preparing a quotation. Availability, MOQ, lead time, and price are confirmed case by case rather than presented as universal figures.

For a more efficient inquiry, I recommend sending your required quantity, preferred purity, application stage, delivery country, packaging expectations, and any requested analytical documents. If your process is sensitive to moisture, metals, or residual solvents, state those requirements at the beginning. This allows Maison Chemical to evaluate the request more accurately and identify the most appropriate supply option.

Key Takeaways

• 4-(Hydroxymethyl)phenylboronic acid, CAS 59016-93-2, is an aromatic boronic acid with a useful hydroxymethyl group for further derivatization.
• The commonly assigned formula is C₇H₉BO₃, and the molecular weight is approximately 151.96 g/mol.
• Buyers should verify identity, assay method, impurity profile, water, residual solvents, packaging, and batch-specific documentation.
• Application suitability should be confirmed through small-scale reaction testing, especially for Suzuki–Miyaura coupling.
• Supplier selection should include technical quality, MOQ, lead time, documentation, repeat-batch capability, and export support.

Conclusion and Next Steps

4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 can be a valuable intermediate when a project needs both an aryl boronic acid coupling site and a hydroxymethyl functionality. The right purchase decision depends on more than the chemical name: I recommend matching the specification to the application, reviewing lot-specific evidence, and assessing the supplier’s ability to support repeat procurement. Before placing an order, request a quotation with your target quantity, purity, delivery location, documentation needs, and any critical impurity limits.

Maison Chemical can support your initial evaluation with product and commercial information tailored to your project stage. Contact our team with your requirements so we can review the appropriate specification, packaging, MOQ, lead time, and supply arrangement for 4-(Hydroxymethyl)phenylboronic acid.

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