3,4,5-Trifluorophenylboronic Acid CAS 143418-49-9 Supplier and Procurement Guide

3,4,5-Trifluorophenylboronic acid, CAS 143418-49-9, is an aryl boronic acid used primarily as a building block in cross-coupling and medicinal chemistry workflows. Its molecular formula is commonly represented as C₆H₄BF₃O₂, with a calculated molecular weight of approximately 175.91 g/mol. As Maison Chemical, we help B2B buyers evaluate identity, specification requirements, packaging, documentation, quantity, and delivery conditions before placing an order.

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The most reliable procurement approach is to define the intended reaction, required purity, analytical documentation, quantity, and destination before comparing suppliers. Buyers should also confirm whether the material is available from stock or requires production scheduling. A supplier quotation is most useful when it clearly separates product price, packaging, shipping terms, lead time, and any applicable export or compliance documentation.

Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical research teams, contract research organizations, chemical manufacturers, university laboratories, and distributors sourcing 3,4,5-trifluorophenylboronic acid. It is especially relevant when the material will be used in route development, small-scale synthesis, process research, or commercial scale-up evaluation. It can also support purchasing teams that need to compare several suppliers using consistent criteria.

I recommend using this information as a procurement framework rather than as a substitute for your internal quality specifications. The correct purchasing decision depends on your reaction conditions, analytical method, batch size, regulatory expectations, and final application. For regulated or safety-critical work, your quality and regulatory teams should approve the final specification before purchase.

Basic Product Context

What 3,4,5-Trifluorophenylboronic Acid Is

3,4,5-Trifluorophenylboronic acid is an organoboron compound containing a boronic acid group attached to a trifluorinated aromatic ring. The boronic acid functionality makes it useful as a coupling partner in carbon–carbon bond-forming chemistry, including Suzuki–Miyaura-type reactions when the reaction system is suitable. The three fluorine substituents can also influence the electronic properties of the aromatic ring and may be valuable during structure–activity relationship studies.

The product should be identified by its chemical name and CAS number rather than by a generic description such as “fluorinated boronic acid.” Similar products can differ in fluorine substitution pattern, molecular weight, physical form, and reactivity. Before approval, I advise buyers to compare the supplier’s certificate of analysis with the requested chemical identity and purchase specification.

Core Specification Points

A buyer may request a nominal purity such as 98% or 99% depending on the application, but the correct target should come from the synthetic procedure and downstream quality requirements. I do not recommend assuming that a higher assay automatically delivers better reaction performance, because moisture, particle characteristics, impurities, and handling history can also affect laboratory results. The supplier should state the actual tested value and method on the batch documentation.

Matching the Material to the Application

For early-stage medicinal chemistry, buyers often prioritize dependable identity, suitable assay, small pack sizes, and fast access for parallel synthesis. For process development, the emphasis normally shifts toward batch consistency, impurity profiles, repeat supply, and documentation that can be reviewed by quality personnel. For larger production planning, packaging, lot traceability, change notification, and supply continuity become increasingly important.

3,4,5-Trifluorophenylboronic acid may be selected when a synthetic route requires this specific substitution pattern. It should not be replaced casually with another fluorophenylboronic acid, because the position and number of fluorine atoms can change molecular properties and product identity. If an alternative is being considered for route optimization, the chemist should confirm the intended structure and evaluate the substitution change experimentally.

Supplier Selection Framework

1. Confirm Technical Fit

Start by sending the supplier the exact product name, CAS number, required quantity, target purity, and intended use category. Include whether the material is for research, process development, manufacturing, or resale. This prevents a quotation based on a similarly named compound or an unsuitable grade.

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2. Review Quality Documentation

Ask for a representative or batch-specific certificate of analysis when available, together with the safety data sheet. Review the identity method, assay method, test date, batch number, and any reported impurity limits. If your organization requires specific analytical techniques such as HPLC, GC, NMR, Karl Fischer water testing, or elemental analysis, state those requirements before order confirmation rather than after shipment.

3. Compare Packaging and Logistics

Packaging should be appropriate for the product quantity and the expected handling environment. Confirm whether the supplier can provide a small laboratory pack, a larger development pack, or a custom quantity, and ask how the container will be labeled for international transport. For export purchases, provide the destination country and delivery address early because shipping restrictions, customs documentation, and dangerous-goods assessment may affect the final quotation.

4. Evaluate Supply Continuity

A low initial price is not the only measure of procurement value. Ask whether the quoted batch is available from stock, made to order, or subject to production allocation, and request an estimated lead time in weeks. If the compound is part of a continuing project, discuss repeat-batch consistency, forecast quantities, and whether the supplier can reserve production capacity based on a non-binding forecast.

Pricing, MOQ, and Lead-Time Considerations

The price of 3,4,5-trifluorophenylboronic acid can vary with purity, packaging, batch size, production status, analytical requirements, destination, and shipping terms. A quotation for 100 g should not be compared directly with a quotation for 1 kg unless the packaging, documentation, and delivery basis are also comparable. I recommend requesting a line-item quotation that identifies product quantity, unit price, packaging, freight, and taxes or duties where applicable.

Minimum order quantity is often influenced by whether the supplier is offering an existing batch or arranging a new production run. A smaller quantity may be available for laboratory evaluation, while a larger quantity may provide better unit economics but require additional quality review. Buyers should also ask whether samples are representative of the commercial batch and whether the quoted lead time begins after payment, purchase order acceptance, or technical approval.

Supplier Evaluation Checklist

• Does the supplier confirm CAS 143418-49-9 and the correct chemical structure?
• Is the requested assay clearly defined, for example as a target of 99% when required by the project?
• Will the shipment include a certificate of analysis and safety data sheet?
• Can the supplier provide the required quantity and packaging format?
• Is the lead time stated in writing, including whether the product is in stock or made to order?
• Can the supplier support repeat orders and batch traceability?
• Are the shipping terms, destination requirements, and export documents clear?
• Is there a defined process for handling deviations, damaged packaging, or quality complaints?

These questions help separate a simple product listing from a dependable B2B supply arrangement. I also suggest comparing the supplier’s responsiveness and technical clarity during the quotation stage, because incomplete answers may create delays later in quality review or customs clearance. The final decision should balance documented quality, total delivered cost, availability, and communication reliability.

How Maison Chemical Supports Procurement

At Maison Chemical, we support buyers by reviewing the required identity, quantity, purity target, packaging, destination, and documentation before preparing a quotation. Our role is to help customers clarify the purchasing specification so that the quoted material aligns with the intended project stage. Where requirements are not yet fixed, we can work from a preliminary inquiry and identify the information needed for a more accurate commercial response.

For B2B inquiries, please provide CAS 143418-49-9, desired quantity, target purity, delivery country, preferred packaging, and required documents. If you need repeat supply, also indicate the expected order frequency and approximate annual demand. This information allows us to assess the appropriate supply route and respond with practical options rather than a generic price.

Key Takeaways

• 3,4,5-Trifluorophenylboronic acid is an aryl boronic acid identified by CAS 143418-49-9 and a molecular weight of approximately 175.91 g/mol.
• Buyers should verify identity, assay, impurity profile, packaging, documentation, stock status, and lead time before placing an order.
• Purity requirements should be defined by the application; a 99% target may be appropriate for some projects but should not be assumed for every use.
• Total procurement value includes delivered cost, documentation quality, supply continuity, and the supplier’s ability to support repeat orders.

Conclusion: Next Steps for Buyers

The best way to source 3,4,5-trifluorophenylboronic acid CAS 143418-49-9 is to issue a complete, application-focused request rather than comparing price alone. Confirm the exact identity, define the required assay and documentation, select a suitable quantity and package, and obtain written information about availability and delivery. These steps reduce the risk of ordering a similar compound or receiving a material that does not match your internal specification.

Maison Chemical can support your next procurement step with a product and quotation review based on your quantity, purity target, destination, and documentation needs. Send us your specification or purchase inquiry, and we will evaluate the appropriate supply option for your research, development, manufacturing, or distribution requirement.

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