3-Fluorophenylboronic Acid CAS 768-35-4: Properties, Uses, and Buying Guide

3-Fluorophenylboronic acid CAS 768-35-4 is an aryl boronic acid used mainly as a building block in palladium-catalyzed Suzuki–Miyaura coupling and related synthetic research. Its key identity data are molecular formula C₆H₆BFO₂ and molecular weight 139.92 g/mol. I recommend selecting this material by verified identity, assay, water content, packaging, and batch documentation rather than by name alone.

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At Maison Chemical, we support research, process development, and commercial sourcing of this fluorinated boronic acid. Because specifications can vary by grade, manufacturing route, and intended application, I encourage buyers to review the current certificate of analysis and confirm the required quality level before placing an order.

Key Takeaways

• 3-Fluorophenylboronic acid, CAS 768-35-4, is an aromatic boronic acid containing both a fluorinated phenyl ring and a boronic acid functional group.
• Its principal value is its ability to participate in carbon–carbon bond-forming chemistry, especially Suzuki–Miyaura coupling.
• The listed molecular weight is 139.92 g/mol, which should be used for stoichiometric calculations and solution preparation.
• Buyers should verify assay, water, impurities, packaging, shelf-life information, and shipping conditions with the supplier.
• Maison Chemical can discuss sample, laboratory, pilot, and larger-volume requirements according to available production and quality documentation.

What Is 3-Fluorophenylboronic Acid?

3-Fluorophenylboronic acid is an organoboron compound in which a boronic acid group is attached to a phenyl ring bearing fluorine at the meta position. The product is also commonly described as 3-fluorobenzeneboronic acid or 3-fluorophenylboronic acid. Its CAS Registry Number is 768-35-4, and its molecular formula is C₆H₆BFO₂.

The boronic acid group is the main reactive feature used in synthetic chemistry. Under suitable reaction conditions, it can react with an aryl or heteroaryl halide to form a new carbon–carbon bond. The fluorine substituent can influence electronic properties, lipophilicity, and downstream molecular design, making this intermediate useful in medicinal chemistry and advanced organic synthesis.

Core Physical and Chemical Information

Appearance, assay, water content, and impurity levels should not be assumed solely from a catalog description. Boronic acids can be sensitive to storage history, moisture exposure, and handling conditions, so the current product specification and certificate of analysis are important for release decisions. If a defined melting range, particle-size distribution, or residual-solvent limit is required, I recommend requesting it before procurement.

How Is It Used?

The most established use of 3-fluorophenylboronic acid is as a coupling partner in Suzuki–Miyaura reactions. In a typical synthesis, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide in the presence of a suitable palladium catalyst, base, solvent, and reaction environment. The outcome depends on the coupling partner, catalyst system, temperature, concentration, and purification method.

Common Application Scenarios

• Medicinal chemistry: preparation of fluorinated biaryl and heteroaryl compounds for screening libraries and lead optimization.
• Pharmaceutical intermediate research: construction of carbon–carbon bonds in multi-step active pharmaceutical ingredient development.
• Agrochemical research: synthesis of substituted aromatic structures used in discovery and process studies.
• Materials chemistry: preparation of functional aromatic molecules and research intermediates.
• Custom synthesis: incorporation of a meta-fluorophenyl fragment into target molecules where electronic or structural effects are required.

This compound is a synthetic reagent and intermediate, not a finished pharmaceutical or agricultural active ingredient. Its suitability must therefore be evaluated within the complete reaction sequence. A successful small-scale reaction does not automatically establish process suitability, regulatory acceptability, or commercial reproducibility.

How to Select the Right Grade

I suggest beginning with the reaction objective rather than choosing the lowest quoted price. For discovery work, buyers may prioritize reliable identity, acceptable assay, and fast sample availability. For process development or manufacturing, the more important factors often include impurity control, lot-to-lot consistency, packaging, documentation, and the supplier’s ability to maintain supply.

Step 1: Define the Technical Specification

Specify the required assay and analytical methods, together with limits for water, residual solvents, inorganic residues, and related organic impurities where relevant. If the material will enter a regulated development program, request the documentation format required by your quality system. I also recommend confirming whether the specification is release-based, customer-specific, or only a general catalog description.

Step 2: Match Quantity to Project Stage

Sample and laboratory quantities are appropriate for route scouting and reaction screening, while pilot or production quantities require a broader supply assessment. Example commercial discussions may involve pack sizes such as 100 g, 500 g, or 1 kg, but actual availability, packaging, and minimum order quantity must be confirmed for the requested batch. Larger requirements should be evaluated with a forecast, target delivery schedule, and acceptance criteria.

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Step 3: Review Storage and Handling Requirements

Keep the container tightly closed and protect the material from unnecessary exposure to moisture, heat, and contamination. Follow the supplier’s current label and safety data sheet rather than applying a universal storage rule. If the supplied specification calls for refrigerated storage, a common controlled range may be 2–8 °C; this condition should be confirmed for the specific product and package.

Step 4: Confirm Analytical Documentation

A useful supplier package may include a certificate of analysis, specification sheet, safety data sheet, batch or lot number, manufacturing date, retest or expiry information where applicable, and shipping documentation. For identity confirmation, buyers may request techniques such as NMR, FTIR, HPLC, GC, or elemental analysis according to the material’s specification. The exact test panel should reflect the risk and use of the product.

Important Buying Factors

Price is only one part of the total purchasing decision. A lower unit price can become less attractive if the supplier cannot provide consistent documentation, suitable packaging, or a realistic delivery schedule. For international procurement, also consider export paperwork, customs requirements, dangerous-goods classification if applicable, and the effect of transit time on product integrity.

Lead time should be quoted against a defined quantity and specification. Stock availability, production scheduling, quality release, and export preparation can all affect the final dispatch date. At Maison Chemical, we prefer to review the required CAS number, quantity, destination, packaging, and documentation expectations before confirming a commercial offer.

Supplier Evaluation Checklist

1. Does the supplier clearly identify the product as CAS 768-35-4?
2. Are the molecular formula and molecular weight consistent with the requested material?
3. Can the supplier provide a current certificate of analysis for the offered batch?
4. Are assay, water, impurities, and appearance defined in a usable specification?
5. Can the supplier explain packaging, storage, shelf-life, and transport conditions?
6. Are MOQ, lead time, sample policy, and repeat-order capability stated clearly?
7. Can the supplier support custom documentation or a customer-specific specification when needed?

Limitations and Common Mistakes

One common mistake is treating all aryl boronic acids as interchangeable. The position of fluorine changes the structure, and 3-fluorophenylboronic acid should not be substituted with a 2-fluoro or 4-fluoro isomer without checking the reaction and product requirements. Another mistake is relying on a product name while overlooking water, impurity, or residual-solvent limits.

Buyers should also avoid assuming that a catalog listing guarantees immediate stock or identical specifications across all lots. Boronic acid materials may require careful handling and should be tested according to the buyer’s own quality procedures. For process use, confirm scale-up behavior, reaction performance, isolation requirements, and impurity carryover through appropriate technical evaluation.

How Maison Chemical Supports Buyers

Maison Chemical supplies organic boronic acids for laboratory research, process development, and commercial sourcing discussions. For 3-fluorophenylboronic acid CAS 768-35-4, we can review the required quantity, target specification, packaging preference, destination, and documentation needs before quotation. This approach helps align the offered material with the buyer’s actual project stage.

We can also discuss sample evaluation, repeat procurement, export coordination, and customer-specific quality requirements where feasible. Our role is to provide clear product information and practical sourcing support without replacing the buyer’s internal analytical, safety, or regulatory review. Final availability and delivery commitments are confirmed against the specific order inquiry.

Conclusion: Is 3-Fluorophenylboronic Acid CAS 768-35-4 Right for Your Project?

3-Fluorophenylboronic acid CAS 768-35-4 is a useful fluorinated aryl building block, particularly for Suzuki–Miyaura coupling and related organic synthesis. Its core identifiers are C₆H₆BFO₂, molecular weight 139.92 g/mol, and CAS 768-35-4. The right purchasing decision depends on verified quality, application fit, handling requirements, quantity, documentation, and dependable supply.

As a next step, send Maison Chemical your required quantity, assay or impurity specification, packaging preference, destination, and target delivery schedule. We can then review the appropriate grade, provide current commercial information, and identify the documentation needed for your evaluation. Contact Maison Chemical for a product inquiry when you are ready to compare a sample, pilot supply, or larger-volume sourcing option.

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