What Is 4-Benzyloxy-2-methylphenylboronic Acid CAS 847560-49-0 Used For?

4-Benzyloxy-2-methylphenylboronic acid, identified by CAS 847560-49-0, is primarily used as a specialized aryl boronic acid intermediate in organic synthesis and medicinal chemistry research. Its boronic acid group can participate in carbon–carbon bond-forming reactions, while the benzyloxy and methyl substituents provide defined structural features for building more complex aromatic molecules. At Maison Chemical, we support B2B buyers who need this compound for route development, compound-library synthesis, process research, or other non-clinical laboratory applications. The exact suitability depends on the customer’s reaction design, analytical requirements, quantity, and regulatory or shipping conditions.

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Core Functions of 4-Benzyloxy-2-methylphenylboronic Acid

The main function of this compound is to act as an aromatic boronic acid building block. In a suitable palladium-catalyzed Suzuki–Miyaura coupling, the aryl boronic acid functionality may react with an appropriate aryl or heteroaryl halide to form a new carbon–carbon bond. This makes the material useful when a synthetic route requires the controlled introduction of a substituted benzene ring.

The benzyloxy group can also serve as a protected or functionalized oxygen-containing substituent in a synthesis. Depending on the reaction sequence, a chemist may retain this group during coupling and later modify or remove it under conditions selected for the target molecule. The methyl substituent contributes additional steric and electronic characteristics that may be important when designing analogues or optimizing a structure–activity relationship program.

Typical Synthetic Role

• Intermediate for aryl–aryl or aryl–heteroaryl bond construction.
• Building block for medicinal chemistry analogue preparation.
• Starting material for route scouting and small-scale synthesis.
• Substituted aromatic component for research compounds and reference materials.
• Input for developing more advanced intermediates with tailored substitution patterns.

Application Scenarios

Medicinal Chemistry and Compound Discovery

Research chemists may use 4-Benzyloxy-2-methylphenylboronic acid when preparing a series of structurally related compounds. The boronic acid group provides a practical coupling handle, allowing the substituted aromatic unit to be connected with different halogenated partners. By changing the coupling partner, researchers can create analogue libraries for exploratory screening without redesigning the entire synthetic sequence.

Its value in this setting is structural rather than therapeutic. The compound should be considered a research intermediate, not an active pharmaceutical ingredient, finished drug, or demonstrated treatment. Any biological activity belongs to the final synthesized molecule and must be established through independent testing.

Custom Organic Synthesis

Custom synthesis laboratories can evaluate this material as one step in a multi-stage route. It may be selected when the target structure requires a 2-methyl-substituted aromatic ring bearing an oxygen-linked benzyl group or a related transformable functionality. The actual reaction outcome depends on catalyst selection, base, solvent, temperature, substrate compatibility, purification, and the stability of the other reactants.

Process and Route Development

During process research, a buyer may compare this building block with alternative boronic acids or protected phenol derivatives. The comparison normally includes reaction conversion, impurity profile, isolation method, raw-material consistency, and supply continuity. A material that performs well in a discovery-scale reaction still requires additional assessment before it is adopted in a larger process.

Material Options and How to Define Them

For this product, buyers should distinguish between the chemical identity and the commercial specification. The identity is tied to the name and CAS number 847560-49-0, while the specification may include assay, water content, residual solvents, appearance, packaging, and analytical data. Because requirements vary by project, I recommend confirming the specification before placing a purchase order rather than assuming that every supplier offers the same grade.

For early route scouting, a buyer may request a 100 mg or 500 mg sample quantity, while a confirmed synthesis program may require 1 g or more. These quantities are planning examples rather than a product availability claim; Maison Chemical confirms actual pack sizes, minimum order quantity, and stock status for each inquiry. If the material is moisture-sensitive in a customer’s specific workflow, the buyer should also request appropriate packaging and handling information before shipment.

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Key Specifications Buyers Should Review

A useful technical review begins with the product name, CAS 847560-49-0, and the customer’s intended reaction. I suggest asking for the latest certificate of analysis, available chromatographic data, appearance information, and any applicable storage or transport guidance. If a customer has a validated internal method, we can use that method or discuss whether the available analytical package is suitable for preliminary evaluation.

Purity should be interpreted in relation to the planned application. For discovery chemistry, a buyer may establish an internal screening threshold such as 95% or 98% assay, but that threshold must be agreed with the supplier and linked to a defined test method. It should not be treated as the specification of every commercial batch unless it appears in the confirmed quotation or documentation.

Buyer Selection Factors

Reaction Fit

The most important question is whether the compound matches the required substitution pattern and reaction pathway. Buyers should confirm the intended coupling partner, catalyst system, downstream transformations, and impurity tolerance with their chemists. A structurally similar boronic acid is not automatically an interchangeable substitute.

Quality and Documentation

For B2B purchasing, documentation is part of product suitability. Buyers should evaluate whether the supplier can provide batch-specific information, clear labeling, safe-handling documentation where applicable, and consistent communication regarding changes in availability. When the compound will enter a regulated development workflow, the customer should define documentation expectations before commercial discussions.

Supply and Commercial Conditions

Price alone does not determine the best sourcing decision. A lower unit price may be less useful if the available quantity, lead time, packaging, or documentation does not fit the project schedule. I recommend comparing quotations by quantity, specification, delivery location, Incoterms, payment conditions, and the possibility of repeat supply.

How Maison Chemical Supports B2B Sourcing

At Maison Chemical, we position 4-Benzyloxy-2-methylphenylboronic acid as a research-use chemical intermediate for professional customers. Our role is to help buyers clarify the required identity, quantity, specification, packaging, and delivery destination before quotation. We can also review whether the requested documentation and analytical information are available for the intended evaluation stage.

For an efficient inquiry, please provide the CAS number, desired quantity, target purity or assay requirement, destination country, requested delivery schedule, and any special packaging needs. For example, stating whether the request is for 100 mg, 500 mg, or 1 g helps us assess the appropriate commercial route. If the customer expects repeat orders, sharing an estimated annual demand can support a more practical supply discussion without creating an unsupported commitment.

Summary Insight

• 4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is mainly used as a specialized aromatic building block.
• Its boronic acid group supports research-scale carbon–carbon bond-forming chemistry, especially coupling-based route development.
• The compound may be useful in medicinal chemistry, analogue synthesis, custom synthesis, and process research.
• Suitability depends on identity, assay, analytical documentation, reaction compatibility, quantity, and supply conditions.
• Buyers should confirm the actual specification, packaging, MOQ, lead time, and documentation with the supplier.

Conclusion and Next Steps

In direct answer to the question, 4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is used primarily to introduce a defined substituted aromatic fragment into more complex molecules. It is most relevant to synthetic chemistry teams developing research compounds, screening analogues, custom intermediates, or process routes. It should be evaluated as a chemical intermediate, not as a finished pharmaceutical or evidence-based therapeutic ingredient.

For the next step, I recommend confirming the target structure, intended reaction, required quantity, purity expectation, and documentation needs. Send these details to Maison Chemical for a product and supply review, including availability, packaging, quotation basis, and delivery feasibility. This approach helps buyers select the material according to real project requirements rather than relying on the chemical name alone.

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