What Is 4-Aminophenylboronic Acid Picol Ester CAS 214360-73-3?

4-Aminophenylboronic acid picol ester CAS 214360-73-3 is generally used to refer to 4-aminophenylboronic acid pinacol ester, an aromatic boronic ester used as a coupling building block in organic and medicinal chemistry. Its commonly reported molecular formula is C₁₂H₁₈BNO₂, with a molecular weight of approximately 219.09 g/mol. The molecule contains a para-amino-substituted phenyl ring and a boron-containing pinacol ester group, allowing it to participate in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. Because “picol ester” may be a naming variation or typographical error for “pinacol ester,” I recommend confirming the CAS number, structure, and specification before purchasing.

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Definition and Chemical Identity

In practical chemical procurement, CAS 214360-73-3 is associated with 4-aminophenylboronic acid pinacol ester, rather than a conventional “picol ester” designation. The boronic ester protects the boronic acid functionality in a more handling-oriented form while retaining its value as a carbon–carbon bond-forming reagent. The para-amino group also provides a useful functional handle for further derivatization in pharmaceutical, materials, and research chemistry.

The compound belongs to the wider family of aryl boronic esters. Its structure combines an aromatic amine with a cyclic boronate ester, so buyers should evaluate both functional groups when assessing compatibility, stability, and downstream reaction requirements. PubChem and other chemical databases should be used to cross-check the identity, formula, synonyms, and structure against the supplier’s current technical documents.

Authoritative reference: The National Center for Biotechnology Information, PubChem, provides compound identity and chemical-property records through its compound database: PubChem.

Core Functions in Organic Synthesis

Suzuki–Miyaura Coupling Building Block

The primary function of this material is to provide an aryl boronate partner for cross-coupling. Under an appropriate catalytic system, the aryl–boron group can react with an aryl or vinyl halide to form a new carbon–carbon bond. The exact conversion depends on the catalyst, base, solvent, temperature, substrate, and reaction time, so I do not recommend treating one literature condition as universally applicable.

Its para-amino substituent can remain in the product or be protected before coupling, depending on the reaction design. Chemists may use protecting groups when the free amine interferes with catalyst coordination, acid–base balance, solubility, or selectivity. Process development should therefore include a small-scale compatibility study before moving to larger quantities.

Intermediate for Functional Molecule Design

The compound can serve as an intermediate for molecules containing biaryl, heteroaryl, or other conjugated structures. The amino group may support acylation, sulfonylation, urea formation, or other transformations after suitable reaction planning. These possibilities make the material relevant to medicinal chemistry programs and discovery-stage route development, although the final application depends on the target structure.

Application Scenarios

• Medicinal chemistry: preparation of aryl-amine and biaryl analogues during structure–activity relationship studies.
• Pharmaceutical intermediate research: construction of substituted aromatic fragments used in multistep synthesis.
• Fine chemical development: introduction of a para-aminophenyl unit into a more complex molecular framework.
• Materials and ligand research: preparation of functionalized aromatic compounds for further design and screening.
• Process chemistry: evaluation of scalable cross-coupling routes, subject to validated reaction and impurity-control procedures.

These applications are based on the compound’s functional groups and established use of aryl boronic esters in synthetic chemistry. They should not be interpreted as a guarantee of performance in a particular reaction. A project-specific assessment should consider substrate sensitivity, boron reagent stability, catalyst loading, and purification requirements.

Types and Material Options to Consider

Free Boronic Acid Versus Pinacol Ester

The free boronic acid and the pinacol ester are related but distinct materials. The free acid contains the boronic acid functionality directly, whereas the pinacol ester contains a cyclic ester form of the boron group. They may show different solubility, handling, storage, and reaction behavior, so they should not be substituted solely because their names appear similar.

Protected Versus Unprotected Amino Group

CAS 214360-73-3 is generally understood as an unprotected 4-amino derivative. In some synthetic routes, a protected analogue may be more suitable because the amine can influence catalyst behavior or react with other reagents. Buyers should confirm whether the project requires a free –NH₂ group, a protected amine, or a downstream intermediate instead.

Research-Grade and Project-Specific Supply

Commercial material may be offered with different purity targets, analytical packages, packaging sizes, and release criteria. A stated purity percentage should always be connected to a defined analytical method, such as HPLC, GC, NMR, or another method specified on the certificate of analysis. I recommend comparing documents rather than comparing a single headline number.

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Key Specifications Buyers Should Verify

The formula and molecular-weight values above are identity references commonly reported for this compound and should be checked against the supplier’s current specification. Molecular weight calculations are normally expressed in grams per mole, while commercial quantities are commonly quoted in grams or kilograms. For a regulated or scale-up project, the batch-specific COA, SDS, and analytical data should take precedence over a general web listing.

Authoritative reference: IUPAC’s terminology and chemical-nomenclature resources provide the broader framework for interpreting boronic acids, boronic esters, and organic functional groups: IUPAC Gold Book.

Buyer Selection Factors

Identity Confirmation

First, I compare the CAS number, chemical name, molecular formula, molecular weight, and structure drawing. The term “picol ester” deserves particular attention because it may be used inconsistently in search queries and product descriptions. If the requested material is actually the pinacol ester, the supplier should clearly state that identity on the quotation and technical documents.

Purity and Analytical Evidence

For synthetic use, I request a current COA showing the batch number, test method, measured result, and release specification. Depending on the application, useful supporting data may include HPLC or GC purity, NMR confirmation, water content, residual solvents, and elemental or trace-metal information. No single analytical result proves suitability for every route, so the documentation should match the buyer’s process requirements.

Stability and Handling

Boron-containing organic reagents can be sensitive to moisture, heat, light, or prolonged storage conditions depending on their structure and packaging. I recommend following the supplier’s SDS and label instructions rather than applying a generic storage temperature. Buyers should also assess container closure, desiccant use where appropriate, retest policy, and the practical time between dispatch and laboratory use.

Quantity and Supply Planning

Laboratory screening may require only a few grams, while route development can require tens or hundreds of grams. Larger quantities should be discussed early because lead time, packaging configuration, batch continuity, and production scheduling may differ from small-pack supply. For an important synthesis campaign, I recommend reserving sufficient material for development, repeat experiments, and analytical investigation.

Maison Chemical Supplier Support

At Maison Chemical, we support buyers who need to verify the identity and suitability of CAS 214360-73-3 before placing an order. We can discuss the requested name, CAS number, target quantity, purity requirement, application stage, packaging preference, and destination-market documentation. Where available and applicable to the order, we can provide batch-related documents such as a COA and SDS for technical review.

Our role is not to replace the buyer’s reaction validation or quality system. Instead, I focus on helping procurement and technical teams reduce avoidable uncertainty around nomenclature, specification alignment, documentation, and delivery planning. For repeat projects, it is useful to agree on a written specification so that future batches can be evaluated consistently.

Summary Insight

• CAS 214360-73-3 is generally associated with 4-aminophenylboronic acid pinacol ester.
• The commonly reported molecular formula is C₁₂H₁₈BNO₂.
• The approximate molecular weight is 219.09 g/mol.
• The compound combines a para-amino group with an aryl boronic ester functionality.
• Its main synthetic role is as a building block for Suzuki–Miyaura and related coupling research.
• Buyers should confirm the “picol” versus “pinacol” terminology before quotation and shipment.
• Batch-specific COA, SDS, purity method, packaging, and lead-time information should guide the final purchase decision.

Conclusion: What Is This Compound?

4-Aminophenylboronic acid picol ester CAS 214360-73-3 is best verified as 4-aminophenylboronic acid pinacol ester, an aryl boronic ester used to build substituted aromatic and biaryl molecules. Its reported formula is C₁₂H₁₈BNO₂, and its approximate molecular weight is 219.09 g/mol. The boronic ester supports cross-coupling chemistry, while the para-amino group provides an additional site for molecular modification.

As a next step, I recommend sending Maison Chemical the required quantity, target purity, intended use, destination, and documentation requirements. We can then help confirm the nomenclature, review the applicable specification, and coordinate a quotation based on the actual project needs. This approach helps ensure that the material purchased matches the structure and quality requirements of your synthesis plan.

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