What Is 3-(Hydroxymethyl)phenylboronic Acid CAS 87199-15-3? Uses, Specifications, and Buying Information

3-(Hydroxymethyl)phenylboronic acid, identified by CAS 87199-15-3, is an aromatic boronic acid intermediate containing both a boronic acid group and a hydroxymethyl group on a benzene ring. Its molecular formula is commonly represented as C₇H₉BO₃, with a calculated molecular weight of approximately 151.96 g/mol. I supply this product through Maison Chemical for research, process development, and pharmaceutical-intermediate sourcing, subject to application-specific quality and documentation requirements.

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The compound is valuable because its boronic acid functionality can participate in palladium-catalyzed cross-coupling reactions, while the hydroxymethyl group provides an additional handle for downstream functionalization. Buyers should evaluate identity, assay, water content, residual solvents, packaging, and batch documentation rather than selecting only by CAS number. The correct specification depends on whether the material is intended for laboratory synthesis, route scouting, process development, or larger-scale manufacturing.

What Is 3-(Hydroxymethyl)phenylboronic Acid?

3-(Hydroxymethyl)phenylboronic acid is a substituted phenylboronic acid in which a hydroxymethyl group is positioned at the meta, or 3-, position relative to the boronic acid substituent. The molecule therefore combines an aryl boronic acid with a primary alcohol. This structural combination allows chemists to use the boronic acid group for carbon–carbon bond formation and the alcohol group for further derivatization or protection.

As an organoboron compound, it is generally treated as a synthetic building block rather than as a finished active pharmaceutical ingredient. Its practical behavior can be affected by moisture, storage conditions, particle characteristics, and the specific formulation used by a supplier. For that reason, I recommend confirming the current certificate of analysis and handling instructions before placing a production order.

Core Functions and Synthetic Value

Aryl transfer in cross-coupling chemistry

The principal synthetic role of this material is the arylboronic acid functionality. In suitable reaction systems, arylboronic acids can be used in Suzuki-type cross-coupling reactions with compatible aryl or vinyl halides and related electrophiles. The resulting carbon–carbon bond can help construct substituted biaryl, heteroaryl, or vinyl-aryl intermediates used in medicinal chemistry and advanced organic synthesis.

Additional hydroxymethyl reactivity

The hydroxymethyl group provides a separate point of chemical manipulation. Depending on the route design, it may be converted into an ether, ester, halide, protected alcohol, or another functional derivative. This dual functionality can reduce the need for introducing two separate substituents in different synthetic steps, although actual route efficiency must be demonstrated experimentally.

Potential Application Scenarios

Researchers may consider 3-(Hydroxymethyl)phenylboronic acid during the discovery and optimization of pharmaceutical intermediates. It can also be relevant to specialty organic synthesis, building-block libraries, and the preparation of functionalized aromatic compounds. These applications are potential uses based on the compound’s structure; they should not be interpreted as a guarantee of performance in a particular reaction.

In medicinal chemistry, the product may serve as an intermediate for preparing analogues that require a substituted benzene ring with a flexible hydroxymethyl group. In process chemistry, the key questions are often different: reproducible assay, impurity control, filtration behavior, scale-up compatibility, and reliable supply. I therefore work with buyers to distinguish exploratory requirements from manufacturing requirements before confirming a specification.

Types and Material Options Buyers May Encounter

Commercial offerings may differ in assay level, physical form, packaging size, and documentation package. A supplier may offer a research-grade material for small-scale screening, a higher-control batch for process development, or a customized supply arrangement for recurring production. The exact appearance, particle size, and stability profile should be confirmed from the supplier’s current technical documentation instead of being assumed from the chemical name.

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Buyers should also clarify whether the quoted material is supplied as a neat compound or with any formulation, stabilizer, solvent, or special packaging. For a sensitive synthetic route, the presence of trace water or inorganic residues may be more important than a nominal assay difference. At Maison Chemical, I recommend matching the product form to the customer’s reaction and analytical method before finalizing the purchase order.

Key Specifications to Review

The molecular weight of approximately 151.96 g/mol is useful for calculating reaction quantities, but it does not by itself establish product purity or suitability. The CAS number 87199-15-3 supports identity alignment, yet a CAS number should not replace batch-specific testing. For qualified procurement, I suggest requesting a certificate of analysis, safety data sheet, specification sheet, and representative analytical information where available.

How Buyers Should Select a Supplier

Match quality requirements to the project stage

For early research, buyers may prioritize availability, small pack sizes, and rapid technical communication. For process development, they usually need stronger lot-to-lot consistency, defined analytical methods, and clearer change-control communication. For commercial or recurring supply, they should additionally review manufacturing capacity, export documentation, packaging controls, production planning, and the supplier’s ability to manage repeat orders.

Evaluate documentation before comparing price

A low unit price is not necessarily the lowest total procurement cost if the material requires additional testing, causes repeated reaction failures, or arrives with incomplete documentation. I recommend comparing the quoted price together with minimum order quantity, sample availability, lead time, shipping terms, shelf-life information, and replacement or investigation procedures. These details help buyers assess sourcing risk more realistically.

Confirm storage and handling expectations

Organoboron compounds and multifunctional aromatic intermediates should be handled according to the supplier’s safety data and product-specific instructions. Buyers should confirm the recommended temperature range, moisture protection, container closure, light exposure guidance, and any re-test or shelf-life policy. Maison Chemical can provide the available handling and shipment information needed for internal receiving and laboratory procedures.

Maison Chemical Supplier Support

As a Chemicals and pharmaceutical-intermediates supplier, Maison Chemical supports B2B customers with product identification, specification alignment, quotation preparation, export coordination, and document review. I can help clarify whether the requested material is intended for laboratory evaluation, route development, or repeat manufacturing supply. This initial discussion helps avoid a mismatch between the customer’s technical needs and the quoted product grade.

Before shipment, buyers should define the required documents and acceptance criteria in writing. Depending on the order and destination, this may include a certificate of analysis, safety data sheet, commercial invoice, packing information, and other agreed export documents. I do not recommend assuming that every document or test is automatically included; it is better to confirm the package during quotation and order review.

Key Takeaways for Buyers

• 3-(Hydroxymethyl)phenylboronic acid is an aromatic boronic acid intermediate with a second hydroxymethyl functional group.
• The product is identified by CAS 87199-15-3 and has a commonly represented formula of C₇H₉BO₃.
• Its approximate molecular weight is 151.96 g/mol, which supports stoichiometric calculations but does not prove batch quality.
• Potential uses include cross-coupling chemistry, medicinal chemistry, specialty synthesis, and pharmaceutical-intermediate development.
• Assay, identity, water, residual solvents, packaging, storage, MOQ, lead time, and documentation should be reviewed together.
• A supplier should be evaluated on technical support and supply reliability as well as price.

Conclusion: Is This the Right Intermediate for Your Project?

3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is a useful multifunctional aromatic building block when a synthesis requires both an arylboronic acid and a hydroxymethyl substituent. Its main value comes from the combination of potential cross-coupling reactivity and additional alcohol-based derivatization. However, the suitability of any batch depends on the reaction, impurity tolerance, handling requirements, and intended scale.

My recommended next step is to send Maison Chemical your required quantity, target assay or impurity limits, application stage, destination country, packaging preference, and requested documents. I can then help prepare a practical quotation and confirm the available specification, MOQ, lead time, and shipping arrangement. This structured approach gives qualified B2B buyers a clearer basis for deciding whether 3-(Hydroxymethyl)phenylboronic acid is appropriate for their synthesis and supply plan.

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